PHARMACOLOGY FURTHER E-NEWSLETTER
February '24
Is Pharmacology Difficult®️
FEBRUARY FDA APPROVED DRUGS :
Budesonide Oral Suspension (Eohilia) was approved on February 9, 2024 for the treatment of Eosinophilic Esophargitis. It is a mucoadherent formulation
Iloprost Injection(Aurlumyn) was approved on February 13, 2024 for treatment of frostbite. It is a prostacyclin mimetic used to treat frostbite and reduce incidences of amputation of the digits.
Lifileucel I.V. Infusion Suspension (Amtagvi) was approved on February 16, 2024 for the Adults suffering from Metastatic Melanoma. It is a tumour derived autologous T-cell immunotherapy.
Cefepime and Enmetazobactam Injection (Exblifep) was approved on February 22, 2024 for the treatment of Urinary Tract Infection especially complicated one. It is a fourth generation cephalosporin and beta lactamase inhibitor.
Adalimumab-ryvk injection (Simlandi) was approved on February 23, 2024 for the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis, Uvietis, Crohn’s disease, Ankylosing Spondylitis, etc. Mechanism of action of this drug is by blocking Tumor Necrosis Factor (TNF ) , biosimilar to Humira.
Letibotulinum toxin-wlbg powder for Injection (Letybo) was approved on February 29, 2024 for the treatment of Glabellar lines. The mechanism of action of the drug is by inhibiting the release of Acetylcholine and also as Neuro muscular blocking agent.
LATEST MEDICAL UPDATES:
It has been researched that - Regular and distracting musculoskeletal pain has been the leading cause of quitting and retiring from work much before than expected age.
Studies from German Institute have demonstrated in a mouse model that metformin has always been frequently prescribed during pregnancy with the view of gestational diabetes in mind, has no harmful effect on the offspring as it can cross the placental barrier.
It has been found with great research that if the lungs are severely infected during covid infection , then the danger can spread to heart too!
Scientists of John Hopkins University have suggested that Artificial Intelligence can now detect infected lung tissue owing. to severe Covid 19 infection.
Novel researches from University of Sheffield have warned against health risks developed by consuming drinking water containing arsenic much higher than recommended levels.
FROM MY CLASSROOM:
Here I will be sharing some insights of Pharmacology learnings from the classes I have taken this month or all that I have read in the subject.
My own reading topic comprises of Migraine and its treatment:
Definition- Migraine is a unilateral pulsatile throbbing headache. The outcomes are usually tiredness, nausea, vision disturbances, etc
They adversely affect your social and personal life
They can be classified as Migraine with aura and migraine without aura.
Accordingly the various stages of Migraine are: Prodrome, Aura, Headache
Genetics play a great good role in migraine aetiology, other causes are hormonal changes, stress, too much coffee or tobacco, overexertion, loud noise, lights, etc.
Treatment for mild conditions initially involves use of Non Steroidal Anti Inflammatory Drugs (NSAIDs) E.g.s- Ibuprofen, Aspirin, Acetaminophen, etc.
But if the pain and problem is moderate to severe, addition of drugs like “Triptans” is done- most common being Sumatriptan, Zolmitriptan, Rizatriptan
Other group of drugs are- Ditans which interfere with release of CGRP-(lasmiditan), Gepants which also supress CGRP-(Rimegepant, Ubrogepant), Ergotamines and dihydroergotamines, Antiemetic drugs like metoclopramide.
Migraine prophylaxis is also very important topic of study. Special and many drugs are used for this purpose. Drugs used are Anticonvulsants like Valproic acid and Topiramate, Beta blockers like Propranolol, Calcium channel blockers like Verapamil and Flunarizine, Tricyclic antidepressants like Amitriptyline and Nortriptyline, Serotonin and Norepinephrine reuptake inhibitors like Venlafaxine and Duloxetune and monoclonal antibodies like erenumab and galcanezumab, etc
Home tips and remedies to calm and soothe during migraine ar to sit and relax in quiet and dark room, applying cold or warm compresses, massaging scalp and pressing temples and rotating them in circular motion.
Radgin Wiz®️
From Radgin Wiz Writing desk:
Recently I had planned to write the book Demitasse diary but a new project came to my mind
Firstly I have been busy collecting and researching material for the “Drugs precis” series and was quite able to do so.
Secondly my visit to Banglore brought new stuff, insights and material for the book to write “Afresh” !!
So I planned to write my second travel memoir-” Bangalore and Bingo!!!” .
This gonna be most probably my April Camp Nanowrimo project thing.
SIMPLE AND SPARKLING:
Mushrooms are Veg!!
Oh Yes!! Mushrooms are veg food!
Both toxic and non toxic varieties of mushrooms are found but edible non toxic variants are quite healthy and rich in minerals and vitamins
Mushrooms are rich in antioxidants especially selenium. They are also rich in Beta glucan- a soluble dietary fibre which works by reducing excess bad cholesterol and being beneficial for heart health. It can aid to regulate blood sugar and prove to be useful in diabetes type 2 .
Mushrooms are rich source of Copper, Thiamine, magnesium, Phosphorous and Potassium also.
Mushrooms help by boosting immune system and lowering blood pressure
Cremini and Button mushrooms are most common edible varieties. Oyester, Enoki and Morel are also edible variants.
They protect the brain, help fight carcinogens and are a good source of vitamin D
Wild mushrooms grow in nature- should not be consumed as they are poisonous. Mushroom poisoning can occur in few hours of eating them. The signs and symptoms are Confusion, nausea, sweating, excitability, Dilated pupils, difficulty in breathing and diarrhoea.
The variety Amanita muscaria and Amanita phalloides is actually fatal if eaten.
Delayed mushroom poisoning can be treated with Atropine to reduce excess cholinergic symptoms
Early treatment includes supportive care, activated charcoal.
Off the Cuff Talks
Benefits of reading newspaper:
Newspaper reading updates general knowledge
You can read any language newspaper of your choice and enrich your vocabulary and knowledge
Comprehension and reading skills enhance and improve
A good reader can always become a good writer
With latest news and advertisements you can always stay ahead in your career
You become an active learner and enhance public speaking skills
Biographies and examples of people’s lives teaches lessons and motivates you to stay intact o the path of dutifulness, loyalty and follow moral values in life and become a good, responsible citizen
Reading a newspaper daily cultivates a global opinion, overview and perspective
Children can progress in their Language subjects and subjects like science and social science if they daily read newspaper and stay in touch with latest updates and researches.
All in all- Newspaper reading , rather any kind of reading is simply a great learning activity and habit adopted by anybody who wishes to stay disciplined, informed, updated and progressive!!
That is all from my end for the month of February’24! Hope you all maintain your reading curiosity, skills and habit and enjoy this peice of writing for the month from my end!!