PHARMACOLOGY FURTHER E-NEWSLETTER

MARCH '25

Is Pharmacology Difficult®️

MARCH FDA APPROVED DRUGS :

• Omalizumab-Igec (Omlyclo) injection- was approved on March 7, 2025 for the treatment of Asthma, treatment of Rhinosinusitis with nasal polyps, food allergies and urticaria. It is an Anti IgE Antibody interchangeable biosimilar to Xolair for the treatment of Asthma, etc

• Losartan Potassium (Arbli) Oral suspension- was approved on March 13, 2025 for the treatment of High Blood pressure and Diabetic Kidney Disease (Nephropathy). Its an oral liquid formulation of Angiotensin 2 receptor blocker

• Gallium Ga 68 Gozetotide (Gozellix) Injection Kit- was approved on March 20, 2025 for the treatment of Positron Emission Tomography Imaging. It is a radioactive diagnostic agent. It helps in PET of Prostrate specific membrane antigen (PSMA) positive lesions in men with prostrate cancer.

• Gepotidacin (Blujepa) tablets- was approved on march 25, 2025 for the treatment of Urinary Tract Infection. It is triazaacenaphthylene bacterial type 2 Topoisomerase inhibitor used for cure of uncomplicated UTI

• Diazoxide Choline (Vykat XR) extended Release tablets - was approved on March 26, 2025 for the treatment of Prader Willi Syndrome. It is an extended release formulation of crystalline salt of diazoxide for use in treatment of hyperphagia associated with Prader Willi syndrome.

• Fitusiran (Qfitilia) Injection- was approved on March 28, 2025 for the treatment of Hemophilia A, Hemophilia A with Inhibitors, Hemophilia B, Hemophilia B with Inhibitors. It is an Antithrombin directed small interfering ribonucliec acid for the prohylactic treatment of people suffering from Hemophilia A, Hemophilia A with Inhibitors, Hemophilia B, Hemophilia B with Inhibitors.

LATEST MEDICAL UPDATES:

Latest research:

• Latest research shows that coffee impacts women positively with growing age. It minimises risk of liver problems and diabetes, less memory impairments, less mental health problems.

• Recent study shows that simple blood test and measuring intrinsic capacity. It is sum of person’s physical and mental capacity and is a measure of ageing. This can now be assessed with single drop of blood or saliva. It can be done by measuring DNA methylation in blood samples.

• Latest studies show that two servings of mangoes daily can reduce bad cholesterol and lower blood pressure especially in postmenopausal women.

• A current ongoing study by Erin Mauney is on its way to unfold a wonderful news that “Psilocybin”- an ingredient in magical mushrooms is quite supportive and might be useful to treat Irritable Bowel Syndrome (IBS).

• Latest study shows that phytosterols rich diet comprising of vegetables and fruits has capacity to lower incidence of heart disease and type 2 diabetes.

FROM MY CLASSROOM:

Here I will be sharing some insights of Pharmacology learnings from the classes I have taken this month or all that I have read in the subject.

My own reading topic comprises of Perimenopause and its signs, care and health tips:

• 🌸 Understanding Perimenopause- Perimenopause is a transition phase before menopause. It begins in late 30s or in 40s and lasts several years.

• Estrogen and Progesterone levels fluctuate, leading to physical and emotional symptoms.

• Periods become irregular- cycles may become long, short, heavy or scarce.

• ⚠️ Common Symptoms- Sudden waves of hot flashes along with bouts of night sweats are the most common discomforts experienced.

• Neurotransmitters are affected way to high- Hormonal dips cause mood swings, irritability or anxiety.

• Women experience many a times insomnia and disrupted sleep patterns.

• Slowing of metabolism is very common- weight gain in abdominal region is very common.

• Signs of decreased libido like - deceased Sexual desire and increased vaginal dryness occur.

• 🌿 Health & Care Tips- Balanced diet rich in nutrients like vitamins, calcium, omega-3s, phytoestrogens should be consumed

• Regular exercise also helps like strength training, walking and yoga help a lot to maintain bone density, mood and weight

• Sleep hygiene should be maintained like calming routines, maintaining cool and dark sleeping space.

• Stress management should be practised like mindfulness, deep breathing, journalling, meditation to manage mood swings and anxiety.

• Regular health check ups should be done to monitor blood pressure, cholesterol, bone density, blood sugar, etc to prevent senile changes.

• One should discuss about HRT, supplements and medicines with doctor.

• One should positively embrace the changes in body, metabolism, one should educate and seek support happily and transform this phase in empowerment and self care.

Radgin Wiz®️

From Radgin Wiz Writing desk:

Finding Joy in your Writing process:

• Write What You Love: When you are too bored from Writing anything, simply sit down and write what you Love! Choose topics, themes, genres that excite you. Passion adds joy to the process

• Writing Rituals: light a candle, play soft music, sip your favourite beverage while writing. Comfortable atmosphere adds joy to the process

• Celebrate small wins: Even little wins- a paragraph or a page- pat yourself on back- you deserve appreciation- celebrate it!

• Write freely, don’t bother about editing- Perfection prevents accomplishment, Be messy- give wings to your creativity

• Use prompts and play- Doodles, word games, writing plays- all can help to make the writing process real fun.

• Place change can help- Changing scenery like switching writing space from room to park to cafe to library to a different place or corner in your home can definitely reignite the writing spark

• Writer friends reunion- Its too lucky to have writer friends and this could be a game changer- two are better than one. Two friends can definitely and positively help to create a writing atmosphere together.

• Reading Inspiration- if somehow one just cannot get idea to write further and fully stuck at thoughts, one can pick up a book randomly and start reading to gather more words, thoughts, ideas , etc

• Maintain a Joy Journal- This may require some practice but if one has- nothing like it. Keep an account of happy writing moments, milestones, small wins , etc.- when you smiled while writing, when a sentence clicked and when a reader appreciated your work.

• Don’t think of End result- Pressure of publishing or even finishing the book can spoil the present moment of writing.

• Write for yourself- to express, explore and enjoy the process!

SIMPLE AND SPARKLING:

COLOURFUL SALADS- IMPORTANT MEAL PORTION:

• Powerhouse of nutrients- Salad colour is due to sparkling variety of veggies and fruits and other ingredients. It offers a broad spectrum of vitamins, minerals and antioxidants important for overall health.

• Detox foods- Salads comprising of cucumbers, greens and citrus fruits flush out toxins and improve kidney and liver health.

• Digestive aid- raw vegetables contain dietary fibre, prevents constipation and aids in gut health.

• Weight management- Salads are good in volume and nutrition but low on calories. They help prevent overeating, ideal to control weight.

• Good in Hydration- Many basic ingredients like lettuce, tomatoes and cucumbers are rich in water content- always keeps them hydrated.

• Enhances Immunity- Beautiful coloured veggies like bell peppers, carrots and beet roots are enriched in Vitamin C and Beta Carotene which enhance immunity.

• Visually captivating- a well prepared and crafted plate of colourful veggies and fruits- is highly appetising and promotes mindful eating- meals are added on with enjoyment and satisfaction.

• Versatility- Salads can be made in a very versatile and customisable fashion adhering to individual needs and tastes and budget and preferences. they can be enjoyed as both main dish or side dish.

Off the Cuff Talks:

Today in “Off The Cuff” Talks, I will talk about "Lessons from a Lazy Afternoon – The Importance of Doing Nothing":

• Rest is important for enhancing productivity-slowing down and resting actually recharges one’s mental and physical batteries.

• Creativity blossoms in stillness-some wonderful ideas knock in the mind when its totally free to wander like during a nap, a walk or staring out of window!

• Presence in the moment- Lazy afternoon teaches one to be present in the moment. Instead of chasing past or future- one should enjoy in the now.

• Emotional reset- In a lazy afternoon, when one does nothing, in absence of all pressures and distractions, one gains clarity and self reflections.

• Living mindfully- one realises that he/she is not a robot but a human being and life is much more and beyond goals, checklists and achievements, etc.

• Joy in Small Things- the unnoticed things become so much noticeable- the running water and sound of wind and rustling leaves. Nature is a complete movie to watch and observe.

• Reduced stress and anxiety- rest lowers cortisol levels, burn out is reduced and nervous system is balanced

• Better choices- once the mind is fully rested, it gets rid of clogging and disarray and better decision making is enhanced.

• Know Yourself better- In silence, golden hours are spent with oneself, you get to know yourself more and better, your thoughts, rhythms and true desires. You build a deeper connection with yourself.

• Freedom from hustle- overall personality development demands balance in life- between activity and rest states, then only a person is mentally and physically firt enough and well prepared for success in life.

Well, That’s all from my end in this Meticulously curated of March ‘25 Issue. Hope it satisfies your quest for information and medical updates and News. Greet you all on the Next issue is (on its way)….

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IT IS A MOTIVATION TO MY EFFORTS…..:))