PHARMACOLOGY FURTHER E-NEWSLETTER
January'24
Is Pharmacology Difficult®️
JANUARY FDA APPROVED DRUGS :
Berdazimer Sodium (Zelsuvmi) was approved on January 5, 2024 for the treatment of Molluscum Contagiosum. It is applied as topical gel. It is a Nitric Oxide releasing agent.
Dupilumab (Dupixent) was approved on January 25, 2024 as only drug for treatment of children one year and older suffering from Eosinophilic Esophagitis.
Gammagard Liquid of Takeda was approved on Januray 29, 2024 for the Adults suffering from Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
LATEST MEDICAL UPDATES:
Numerous non hereditary gene mutations are responsible for the development of EGFR+ Lung Cancer. Chemotherapy always stayed the main treatment therapy. But now Mobocertinib was marketed in around 2021, and it dominantly was adopted as treatment but its failure in Phase 3 trial to reach the end point confirmatory results and its failure in Progression free survival rates forced the manufacturing company to withdraw the drug and cause a lot of limited therapy options to patients suffering from EGFR+ Lung Cancer
Migraine attacks for long time can increase the risk of development of Inflammatory Bowel Disease (IBD) as researched by a Medicine College in Seoul, South Korea.
There is a special mechanism involving Cochlear Zinc in induction of Noise Induced Hearing Loss (NIHL). Studies in mice reveal derangement of Zinc levels caused by loud noise which ultimately lead to hearing damage at cellular level.
Metabolic syndrome is an emerging current problem in western countries. It can be cured and helped upto a certain level with a special “Atlantic Diet” which is made of minimally processed , local and fresh food products.
Researches on mice from Cold Spring Harbour University has shown great potentials in T cells related to longevity and healthy living. The T cells eliminated certain cells in mice and the mice lived a healthy life free from obesity and diabetes.
Current studies from Canada reveals the beneficial use of Magnet guided micro robots in MRI device to treat Liver tumours.
Researches from University of California reveals that the fluid filled. cushion sac around lungs not only serves the protective covering but also treasures flu fighting macrophages.
Researchers from Netherland Cancer Institute have developed an improved and novel stool test to diagnose the colon cancer earlier than the signs and symptoms show off.
Current studies reveal the positive impact of GLP-1 Agonist drugs use and lower risk of anxiety and depression. Drugs like Tirzepatide ans Semaglutide
FROM MY CLASSROOM:
Here I will be sharing some insights of Pharmacology learnings from the classes I have taken this month or all that I have read in the subject.
My own reading topic comprises of Tamsulosin drug and its current status:
You all might have heard about condition of prostatic enlargement known better in medical terms as Benign Prostatic Hyperplasia (BPH). This generally occurs in old age. The drainage of urine is adversely affected from the bladder.
Tamsulosin relaxes the muscles of the prostate and urination is improved.
Disease progression is not improved and prostate continues to enlarge, so surgery is the end point therapy
Tamsulosin is available as a capsule and as only prescription drug.
The mechanism involves blocking of Alpha 1 A receptors (very specifically)
in prostate and relaxing the muscles.
Common side effects of Tamsulosin include dizziness, light headedness, nausea, diarrhoea, blurred vision and painful erection.
Radgin Wiz®️
From Radgin Wiz Writing desk:
I just released my 15th book- “Is Pharmacology Difficult” Book 1 - General Pharmacology - 2nd edition
Coincidently, the first book of mine was the first edition and mean while gaining an experience of 13 books in the middle, the product turned out to be the 2nd edition of the same book.
Definitely, it is an improved version
Next, I think of working on my upcoming project i.e. “Demitasse Diary”
SIMPLE AND SPARKLING:
Let Us Peel The Onions:
Onion (Allium cepa) is a plant which grows in the ground, the bulb is used for food purpose. Cooking onions is easy and hassle free
Onion contains many useful compounds like sulfur which reduce swelling, inflammation, blood cholesterol and sugar. Anti cancer and Antioxidant properties are also found in onions.
There may be instances of eye irritation, allergy . etc.
Applying onion extract on skin may trigger eczema, allergy etc.
Aspirin administered concomitantly may induce allergy or increase sensitivity to onion. When used with anti diabetics, blood sugar may lower down, when used with anticoagulants, healing may slow down. When given with drugs metabolised by CYP2E1 in liver, their metabolism may be slowed down increasing their side effects.
Common side effects include- aggravation of IBS symptoms, may cause heart burn, migraine and bad breath.
Off the Cuff Talks
Pros and Cons of connecting on social media groups:
“INEVITABLE” is what I call the social media groups when you connect with certain group having a few common traits like your school groups, graduation groups, online class groups, etc.
Well, there are many pros and cons of connecting with likeminded people on a group. Before we talk about pros and cons, check your relevance aptly to join the group.
Once convinced about the reason to join the group, definitely there are a bag of mixed emotions dwindling in the mind with different kinds of posts.
It is a true test of your patience and endurance. Like every relationship demands something, similarly the continuity in a group is a true test of tolerance.
It has happened many a times and I have noticed too that for one amicable post , you have to bear with and delete around 50 unwanted and undesirable posts in a week’s time.
One needs to master the art of staying in the social media groups.
Undoubtedly, the groups are a great platform to connect and socially chat, you stay informed, updated and connected!!
It does differ in comfort zone in types of groups, it is much more in family groups and much less in schools and graduation groups.
Everybody has had their shares of sorrows and joys as far as school and graduation memories are concerned. It is sometimes highly irritable to look at the photographs of people whom you felt always disconnected with, who bullied you and pulled your legs during school or graduation times.
But then where does is growing up and maturity at your end guides you? It preaches you silently to ignore and collect the good vibes only. You deserve the best in life and the most beautiful things in life, a handful of people should be not be empowered enough to modify or reshape your happy moods and days.
Still, moods are moods, the cons get darker with impatience and intolerance. When no good reason to stay is served, the final exit is the solution. A few tips can definitely help in these situations to save time, happiness and peace at your corner. The ways are to mute and archive the groups, check the messages once a week at your most insensitive time- the time when you are least concerned about anyone, when you are mentally fit and strong to bear and tolerate anything and everything!
Staying connected is an art and one needs to learn it hard way and surely to survive in the virtual world of social media. one needs to learn to demarcate the fake and the real, the pomp and show and reality and ignore and appreciate the required - All in all stay connected!
That’s a wrap up time for this month of January!! Hope all had a wonderful year start and looking forward to accomplish the most out of the year ahead. With all the best wishes, Thank you, take care!