PHARMACOLOGY FURTHER E-NEWSLETTER
October'23
Is Pharmacology Difficult®️
OCTOBER FDA APPROVED DRUGS :
Etrasimod (Velsipity) was approved on October 12, 2023 for the treatment of Ulcerative Colitis. It is administered orally as tablets. It is Sphingosine 1 Phosphate receptor modulator (S1P).
Bimekizumab-bkzx (Bimzelx) was approved on October 17, 2023 for the treatment of Plaque Psoriasis. It is administered as Injection.
Tenapanor (Xphozah) was approved on October 17, 2023 for the treatment of Hyperphosphatemia of Renal Failure. It is administered as tablets. It is Sodium Hydrogen Exchanger 3 (NHE3) Inhibitor
Zilucoplan (Zilbrysq) was approved on October 17, 2023 for the treatment of Generalised Myasthenia Gravis patients who are Anti-Acetylcholine receptor (AChR) antibody positive. It is administered a an injection. It is peptide inhibitor of Complement component 5 (C5 Inhibitor).
Mirikizumab-mrkz (Omvoh) was approved on October 26, 2023 for the treatment of Ulcerative Colitis. it is administered as Injection. It is an interleukin-23 antgonist.
Vamorolone (Agamree) was approved on October 26, 2023 for the treatment of Duchenne Muscular Dystrophy in 2 year old and above. It is administered as oral suspension. It is a corticosteroid.
Toripalimab-tpzi was approved on October 27, 2023 for the treatment of Nasopharyngeal Carcinoma (NPC). It is administered as Injection. It is a programmed death receptor 1 (PD-1) blocking antibody.
LATEST MEDICAL UPDATES:
Current health researches from University of Granada (UGR) have indicated that daily 8000 steps walked in fact reduces premature death risk and improves quality of life. The best results are obtained when fast speed of walking is maintained. previously Japanese propounded the theory of 10,000 steps daily but without any logic.
Cronkhite Canada syndrome, a rare state of development of non carcinogenic polyps in intestine. This was directly proportional to the high serotonin levels of intestinal epithelium. this is as per research in Baylor College of medicine
It is not only sugar, it is salt too! Yes, current research suggests from Tulane University that people suffering from Type 2 diabetes need to skip salt too!
Current research confirms the effectiveness of JAK Inhibitors- Tofacitinib, Baricitinib and Upadacitinib in treatment of RA, especially when old medicines show less significant effects.
Wasabi is a plant found in Japan and far east Russia, used both as food ingredient and condiment. Already its anti inflammatory benefits are proven, while now its ability of cognitive improvement is also shown. It has calming effects and is useful for both long and short term memory benefits.
A current article and study in Regenerative Medicine suggests that in mice, melanin nanoparticles can actually aid in wound recovery. Proof was established by experimenting on biomimetic models and human skin explants.
FROM MY CLASSROOM:
Here I will be sharing some insights of Pharmacology learnings from the classes I have taken this month and all that I have read in the subject
Well! Well ! Well!
I am the teacher, but of course, teaching is learning:
Tetracyclines-Broad spectrum, resistance by efflux pumps, 4 cyclic rings, doxycycline excreted by liver, forms chelates with milk, etc, deposition in growing teeth and bones, Fanconi syndrome.
Chloramphenicol- very toxic, broad spectrum, limited use, Bone marrow aplasia limiting toxicity, gray baby syndrome
Erythromycin-first drug amongst macrolides, narrow spectrum, inhibitor of CYP3A4 enzymes, acid labile, enteric coated tablets
Azithromycin-Broad spectrum, once daily dosing, no inhibition with CYP3A4 enzymes, better than Erythromycin, acid stable
Clindamycin- Lincosamide antibiotic drug, sometimes effective for VRSA and VRE
Linezolid- Good activity against anaerobes- Bacteroides fragilis
Spiramycin- for toxoplasmosis
Polypeptide antibiotics- topical use mainly
Radgin Wiz®️
From Radgin Wiz Writing desk:
Nanowrimo 2023 is the most awaited and celebrated November month i am looking forward to. It is the National Novel Writing Month 2023 in US
I am planning to write a sequel of my last NaNoWriMo project i.e. “Wizgin and the Valley of the Dwarfs”. This new book name is “Ranjo and the Reckless course of the Aircraft”
This is again a middle grade kids adventure book, this time, the main character is Ranjo.
Got some great reviews for Wizgin and the Valley of the dwarfs
I am sharing the first chapter of the book, “Wizgin and the Valley of the dwarfs” here today free, read it and if you like, o through the whole book :)
CHAPTER 1 THE TINSOP TOWN Once upon a time, there was a beautiful town of Tinsop. The town lay in proximity to the River Dixi. Town was a dream residence of the artists and all the newbie artists used to come and find and build their abodes in Tinsop. Tinsop Artsy weather is worth a mention. It is the apt weather to bloom and nurture. Once visiting Tinsop, nobody could even think of anywhere else. The homes were uniformly built all throughout the town, there was no place of dirt or waste. All the waste and dirt etc was properly disposed of and recycled. The town earned a good fame and reputation owing to the renowned artistic men living there. People of all interests like painting, photography, architecture, theatre, performance art, dancing, video and film art, computer and digital art, calligraphy, abstract expression, etc. stayed there and adorned the town in their best special manners. All the painters of the town had painted their glory covering the town all over. Zig zag, crosswords, parallels, dissections, triangles, circles, squares, chequerboards, and what else can you imagine not to find in the land of Tinsop. The musical artists used to play all types of instruments. The violinists and pianists together organised many concerts of soft music, pop music and countryside music. They used to gather almost more than half of the town population as their spectators. The dancers were a group of masters of all dance forms like contemporary, ballet, latin, tango, jazz, salsa, pole, irish, cuban, etc. LIKING IT... READ THE E-BOOK FROM AMAZON FURTHER
Hope you having a planned, organised writing and reading routine, it could be a simple step like noting things in google calendar - like I do!
SIMPLE AND SPARKLING:
Time to Go Bananas!!
No, I mean time to think about Bananas and their benefits for all of us.
Bananas are rich in fibre
They are very good source of Potassium, Vitamin B6 and Vitamin C
It has many antioxidants and phytonutrients
The protein content is less and no fat is present in bananas
The soluble fibres and the resistant starch in green/unripe bananas help moderate the body’s sugar levels.
Resistant starch serves as prebiotic, which skip the digestion and are harbingers of probiotics- the good gut bacteria
These are weight loss friendly foods and once eaten makes you satisfied for long times, hence you eat less subsequently.
Being rich in potassium, they lower the blood pressure and are cardio friendly too!
Flavonoids, amines are the wonderful antioxidants which are found in abundant in bananas
Supports bone health, ocular health and kidney health and helps to build lean muscle
Curbs down bloating and help in muscle recovery after exercise and wear & tear.
All in all, bananas are very good dietary add ons especially in morning and evening and shakes can help skip meals too!. Good ingredient in weight loss diets and healthy lifestyle!
Off the Cuff Talks
Little things are not really Little, when looked back again, they seem Big things, so enjoy and pay value to them!
Slowly and tastily sip the morning tea or coffee, the first sip is the best thing of the day- enjoy it
As you walk around the garden, pay heed to new sprouting flowers and buds and leaves, they are simply perfect to remind of new beginnings!
Don’t ignore the comments (positive and critical) by your mom when you dress up for office in the morning, they are simply the best advice pieces for you!
Do not ignore the Good morning and greetings in the morning by your friends and colleagues, they are meant to be responded with the early morning zest and purity
Do not ignore the knowledge of anyone’s birthday when person is in reach- and make an effort to wish. You may be the first or only one to wish them Happy Birthday!
Money is not important, it is the inner peace which actually ranks higher than achievement- just try sacrificing something worthwhile for inner peace- its worth it and stay HAPPY!
We all are striving hard and making efforts: to be Happy! Healthy! and Peaceful! Nothing is more desirable o this planet- AM I RIGHT?
Fine, IT’S A WRAP O’CLOCK
I look forward to see and talk to you all again but at a month's span.
Till then,
the clock gonna tick,
don’t you miss
let every act, every thought,
rejuvenate and kindle the extent of bliss
Cos' the next time we sit
and while the tea we sip,
in your talks I wish,
we rejoice and celebrate your wins!
J'ai hâte de vous revoir et de vous parler à nouveau mais dans un mois.
D'ici là, l'horloge va sonner,
ne te manque pas
que chaque acte, chaque pensée,
rajeunir et allumer l'étendue du bonheur
Parce que la prochaine fois que nous nous asseyons et que pendant que nous sirotons le thé, dans vos discussions, je souhaite, nous nous réjouissons et célébrons vos victoires !
Yes, my convo is to be supplemented with the final fulls stop!
Chao till the next monthly meeting, à bientôt, au revoir